A 7-year-old child is noted to have 2+ protein on urinalysis. A 24-h collection of urine reveals a protein excretion of 2.5 g/24 h. A thorough history might reveal ingestion of which of the following medications?
a. Tetracycline
b. Streptomycin
c. Trimethadione
d. Diazepam
e. Chlorambucil
The answer is c. The patient described appears to have nephrotic syndrome (protein excretion of greater than 2 g/24 h). Drug-related nephrotic syndrome has been described in connection with the use of trimethadione, penicillamine, captopril, probenicid, ethosuximide, methimazole, lithium, procainamide, chlorpropamide, phenytoin, paramethadione, tolbutamide, some of the nonsteroidal anti-inflammatory drugs (NSAIDs), and certain heavy metals (e.g., gold, mercury-containing medications).
a. Tetracycline
b. Streptomycin
c. Trimethadione
d. Diazepam
e. Chlorambucil
The answer is c. The patient described appears to have nephrotic syndrome (protein excretion of greater than 2 g/24 h). Drug-related nephrotic syndrome has been described in connection with the use of trimethadione, penicillamine, captopril, probenicid, ethosuximide, methimazole, lithium, procainamide, chlorpropamide, phenytoin, paramethadione, tolbutamide, some of the nonsteroidal anti-inflammatory drugs (NSAIDs), and certain heavy metals (e.g., gold, mercury-containing medications).
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